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KMID : 1098420080160050294
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 5 p.294 ~ p.300
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Immuno-Regulatory Effect on Centella asiatica L. Urban Extraction Solvent Associated with Ultrasonification Process
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Kwon Min-Cheol
Han Jae-Gun
Ha Ji-Hye
Oh Sung-Ho
Kim Young
Jeong Hyang-Suk
Choi Geun-Pyo
Hwang Baik
Lee Hyeon-Yong
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Abstract
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This study was performed to investigate the increasing of immune activities from Centella asiatica L. Urban by several solvent extraction with ultrasonification process. Ethanol extracts at and associated with ultrasofication showed more 15% yield than normal water extracts. And ethanol extracts showed higher yield than water extraction at each process. It can be concluded that yield due to polarity of compound in C. asiatica from HPLC peak. All of extracts from C. asiatica revealed lower cytotoxicity than 32%. The ethanol extracts with ultrasofication showed higher promotion on human B and T cell growth, about 10% compared to the control. The secretion of IL-6 and TNF-a was also enhanced as and each, by the addition ethanol extracts with ultrasonification to T cell. NK cell activation was improved up to 10% higher than the control, through adding the samples. It can be concluded that the ethanol extracts from C. asiatica has higher immune activities followed by ultrasonification process, possibly, by higher yield than conventional extraction process.
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KEYWORD
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Centella asiatica L. Urban, Immune Activity, Solvent, Extraction, Ultrasonification
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